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Jamie Lynn Sigler On MS, Motherhood, and Living Without Hiding Her Diagnosis

podcast July 1, 2026


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Jamie Lynn Sigler grew up in front of the world as Meadow Soprano, one of television’s most iconic daughters. But while she was coming of age on screen, she was privately carrying a secret that almost nobody knew: at age 20, she was diagnosed with multiple sclerosis. For 14 years, she hid her diagnosis from Hollywood, her coworkers, and her friends out of fear and shame.

Now, Jamie sits down with Hoda Kotb to pull back the curtain on a life no longer built on perfection, but on radical honesty. She opens up about her deeply moving memoir, And So It Is, which begins with a terrifying medical crisis involving her young son, Beau. Jamie shares how she broke through the paralyzing loop of childhood trauma through EMDR therapy, what it was like to finally confide in her late co star James Gandolfini, and how she found peace by letting go of the need to pretend she was always fine.

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